Why Our Arteries Become Clogged As We Age
The endothelium’s ability to manufacture enough nitric oxide to maintain artery dilation is one of its most crucial functions. When arteries lose their ability to respond to a sudden increased demand for blood flow, endothelial dysfunction develops. This condition is a hallmark of the cardiovascular disease.
//www.medreviews.com/ pdfs/articles/RIU_5Suppl7_S21.pdf. Accessed April 20, 2005.
PLC passes across the mitochondrial membrane to supply L-carnitine directly to the mitochondria, the energy-producing organelles of all cells. Carnitines are essential for mitochondrial fatty acid transport and energy production. This is important because heart muscle cells and endothelial cells burn fatty acids rather than glucose for 70% of their energy. By contrast, most cells generate 70% of their energy from glucose and only 30% from fatty acids.56
Herz. 1987 Feb;12(1):41-50.
ATP benefits muscle growth, recovery, and strength, and lessens the perception of fatigue and exercise-associated pain
Atherosclerosis remains the number-one cause of death and disability in the United States
The endothelium’s ability to manufacture enough nitric oxide to maintain artery dilation is one of its most crucial functions
Propionyl-L-carnitine quickly penetrates into heart muscle cells,43 an effect thought to account for its superiority in supporting heart muscle recovery
Cardiovasc Res. 2001 Jul;51(1):21-9.
- Endothelial dysfunction is a critical factor in the initiation and progression of cardiovascular disease.
- propionyl-L-carnitine appears to work by protecting heart muscle cells from damage caused by lack of blood flow
propionyl-L-carnitine…in increasing muscle energy
propionyl-L-carnitine could combat the destructive effects of low oxygen status and muscle
fatigue Int J Clin Pharmacol Res. 1990;10(3):197-202
By 1997, propionyl-L-carnitine was found to contribute to the body’s ability to increase muscle glycogen
As the amount of functioning mitochondria decreases, many of the “symptoms” of aging manifests. In part, this occurs because of the mitochondria’s continual burning of fatty acids to produce energy. In the process of releasing energy, huge bursts of oxidant compounds damage mitochondria and the cells that contain them. This steady assault leads to the gradual loss of mitochondrial function in all of our tissues.5
Antioxid Redox Signal. 2010 Apr;12(4):503-35
Interdiscip Top Gerontol. 2010;37:142-56.
PLC passes across the mitochondrial membrane to supply L-carnitine directly to the mitochondria, the energy-producing organelles of all cells. Carnitines are essential for mitochondrial fatty acid transport and energy production. This is important because heart muscle cells and endothelial cells burn fatty acids rather than glucose for 70% of their energy. By contrast, most cells generate 70% of their energy from glucose and only 30% from fatty acids.56
Herz. 1987 Feb;12(1):41-50.
ATP benefits muscle growth, recovery, and strength, and lessens the perception of fatigue and exercise-associated pain
The age-related decline in mitochondrial activity is largely responsible for cardiovascular and neurological disorders as well as obesity and type II diabetes.
Simply put, a carnitine deficiency leads to the wholesale destruction of our mitochondria
As the amount of functioning mitochondria decreases, many of the “symptoms” of aging manifests. In part, this occurs because of the mitochondria’s continual burning of fatty acids to produce energy. In the process of releasing energy, huge bursts of oxidant compounds damage mitochondria and the cells that contain them.4 This steady assault leads to the gradual loss of mitochondrial function in all of our tissues.5
The age-related decline in mitochondrial activity is largely responsible for cardiovascular and neurological disorders as well as obesity and type II diabetes.6-9 Loss of mitochondrial function in muscle tissue also leads to the familiar “flabby” body composition we associate with older people because it causes muscle atrophy and increased body fat mass.10 From this list, you can see how essential carnitine is to your daily health.
Total carnitine levels in aging individuals are roughly 20% lower than in youth,11 which leaves mitochondria increasingly vulnerable to damage.
Fortunately, studies have proven that supplementing with carnitine can restore mitochondrial function to near-youthful levels.
J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1027-33.
Aging Dis. 2011 Jun;2(3):242-56.
Ann N Y Acad Sci. 2010 Jul;1201:157-65
An advanced evaluation shows that acetyl-L-carnitine produces a 70% reduction in one measurement of Advanced Glycation End products (AGE’s) It is the formation AGE’s that make cataract’s irreversible.
(England) Jul 1999, 69 (1) p109-15